|
KMID : 1130620120080040308
|
|
Journal of Clinical Neurology
2012 Volume.8 No. 4 p.308 ~ p.310
|
|
|
Exofocal Anterograde Transsynaptic Neuronal Death in the Globus Pallidus: Two Case Reports
|
|
Koo Min-Woo
Kim Yue-Kyung
Ku Kyung-Mo
Park Won-Wha
Minn Yang-Ki
|
|
|
Abstract
|
|
|
Background: Exofocal neuronal death in the substantia nigra (SN) is a well-known form of anterograde transsynaptic cell death. Exofocal neuronal death could theoretically also occur in the globus pallidus (GP) after striatal injury.
Case Report: Case 1. A 70-year-old woman visited the emergency room because of decreased mentality. On admission, blood-gas analysis indicated that her oxygen tension was 69.1 mm Hg. The caudate nucleus, putamen, and temporooccipital cortex on both sides of the brain exhibited high-intensity diffusion-weighted magnetic resonance imaging (MRI) signals. At 10 days after admission, new high-intensity signals had developed in the SN and GP on both sides. Case 2. A 48-year-old man visited the emergency room because of right-sided weakness. Lesions were noted in the left caudate nucleus and putamen. At 4 days after admission, newly developed high-intensity MRI signals were observed in the left SN and GP.
Conclusions: Exofocal neuronal death can occur in the GP as well as in the SN; these findings need to be clearly distinguished from those of recurrent ischemic injuries, such as recurrent stroke.
|
|
|
KEYWORD
|
|
|
transsynaptic, degeneration, globus pallidus, substantia nigra
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|